NMR Detection of Structures in the HIV-1 5´-Leader RNA that Regulate Genome Packaging

The 5´-leader of the HIV-1 genome regulates multiple functions during viral replication by mechanisms that have yet to be established. We developed an NMR approach that enabled direct detection of structural elements within the intact leader (712 nucleotide dimer) that are critical for genome packag...

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Main Authors: Lu, Kun, Heng, Xiao, Garyu, Lianko, Monti, Sarah, Garcia, Eric L., Kharytonchyk, Siarhei, Dorjsuren, Bilguujin, Kulandaivel, Gowry, Jones, Simonne, Hiremath, Atheeth, Divakaruni, Sai Sachin, LaCotti, Courtney, Barton, Shawn, Tummillo, Daniel, Hosic, Azra, Edme, Kedy, Albrecht, Sara, Telesnitsky, Alice, Summers, Michael F.
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335204/
https://ncbi.nlm.nih.gov/pubmed/21998393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1210460
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