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Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
The promoter in HIV type 1 (HIV-1) proviral DNA contains three sequential guanosines at the U3–R boundary that have been proposed to function as sites for transcription initiation. Here we show that all three sites are used in cells infected with HIV-1 and that viral RNAs containing a single 5′ capp...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5127319/ https://ncbi.nlm.nih.gov/pubmed/27834211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616627113 |
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