Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome

The promoter in HIV type 1 (HIV-1) proviral DNA contains three sequential guanosines at the U3–R boundary that have been proposed to function as sites for transcription initiation. Here we show that all three sites are used in cells infected with HIV-1 and that viral RNAs containing a single 5′ capp...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kharytonchyk, Siarhei, Monti, Sarah, Smaldino, Philip J., Van, Verna, Bolden, Nicholas C., Brown, Joshua D., Russo, Emily, Swanson, Canessa, Shuey, Alex, Telesnitsky, Alice, Summers, Michael F.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127319/
https://ncbi.nlm.nih.gov/pubmed/27834211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616627113
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