NMR Detection of Structures in the HIV-1 5´-Leader RNA that Regulate Genome Packaging

The 5´-leader of the HIV-1 genome regulates multiple functions during viral replication by mechanisms that have yet to be established. We developed an NMR approach that enabled direct detection of structural elements within the intact leader (712 nucleotide dimer) that are critical for genome packag...

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Bibliographic Details
Main Authors: Lu, Kun, Heng, Xiao, Garyu, Lianko, Monti, Sarah, Garcia, Eric L., Kharytonchyk, Siarhei, Dorjsuren, Bilguujin, Kulandaivel, Gowry, Jones, Simonne, Hiremath, Atheeth, Divakaruni, Sai Sachin, LaCotti, Courtney, Barton, Shawn, Tummillo, Daniel, Hosic, Azra, Edme, Kedy, Albrecht, Sara, Telesnitsky, Alice, Summers, Michael F.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335204/
https://ncbi.nlm.nih.gov/pubmed/21998393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1210460
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