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Targeted Overexpression of Osteoactivin in Cells of Osteoclastic Lineage Promotes Osteoclastic Resorption and Bone Loss in Mice

This study sought to test whether targeted overexpression of osteoactivin (OA) in cells of osteoclastic lineage, using the tartrate-resistant acid phosphase (TRAP) exon 1B/C promoter to drive OA expression, would increase bone resorption and bone loss in vivo. OA transgenic osteoclasts showed ∼2-fol...

詳細記述

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書誌詳細
主要な著者: Sheng, Matilda H.-C., Wergedal, Jon E., Mohan, Subburaman, Amoui, Mehran, Baylink, David J., Lau, K.-H. William
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335057/
https://ncbi.nlm.nih.gov/pubmed/22536365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035280
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