Targeted Overexpression of Osteoactivin in Cells of Osteoclastic Lineage Promotes Osteoclastic Resorption and Bone Loss in Mice

This study sought to test whether targeted overexpression of osteoactivin (OA) in cells of osteoclastic lineage, using the tartrate-resistant acid phosphase (TRAP) exon 1B/C promoter to drive OA expression, would increase bone resorption and bone loss in vivo. OA transgenic osteoclasts showed ∼2-fol...

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Detalhes bibliográficos
Principais autores: Sheng, Matilda H.-C., Wergedal, Jon E., Mohan, Subburaman, Amoui, Mehran, Baylink, David J., Lau, K.-H. William
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335057/
https://ncbi.nlm.nih.gov/pubmed/22536365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035280
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