Targeted Overexpression of Osteoactivin in Cells of Osteoclastic Lineage Promotes Osteoclastic Resorption and Bone Loss in Mice

This study sought to test whether targeted overexpression of osteoactivin (OA) in cells of osteoclastic lineage, using the tartrate-resistant acid phosphase (TRAP) exon 1B/C promoter to drive OA expression, would increase bone resorption and bone loss in vivo. OA transgenic osteoclasts showed ∼2-fol...

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Detaylı Bibliyografya
Asıl Yazarlar: Sheng, Matilda H.-C., Wergedal, Jon E., Mohan, Subburaman, Amoui, Mehran, Baylink, David J., Lau, K.-H. William
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335057/
https://ncbi.nlm.nih.gov/pubmed/22536365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035280
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