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Automatic Design of Synthetic Gene Circuits through Mixed Integer Non-linear Programming

Automatic design of synthetic gene circuits poses a significant challenge to synthetic biology, primarily due to the complexity of biological systems, and the lack of rigorous optimization methods that can cope with the combinatorial explosion as the number of biological parts increases. Current opt...

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Autores principales: Huynh, Linh, Kececioglu, John, Köppe, Matthias, Tagkopoulos, Ilias
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334995/
https://ncbi.nlm.nih.gov/pubmed/22536398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035529
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