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Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity
Nlrp1b is a NOD-like receptor that detects the catalytic activity of anthrax lethal toxin and subsequently co-oligomerizes into a pro-caspase-1 activation platform known as an inflammasome. Nlrp1b has two domains that promote oligomerization: a NACHT domain, which is a member of the AAA+ ATPase fami...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Public Library of Science
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3334886/ https://ncbi.nlm.nih.gov/pubmed/22536155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002659 |
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