Expression of Nlrp1b Inflammasome Components in Human Fibroblasts Confers Susceptibility to Anthrax Lethal Toxin

Anthrax lethal toxin causes macrophages and dendritic cells from some mouse strains to undergo caspase-1-dependent cell death. Central to this process is the NOD-like receptor Nlrp1b (Nalp1b), which detects intoxication and then self-associates to form a complex, termed an inflammasome, that is capa...

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Bibliographic Details
Main Authors: Liao, Kuo-Chieh, Mogridge, Jeremy
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747971/
https://ncbi.nlm.nih.gov/pubmed/19651869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00276-09
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