Structures of The HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of The AIM2 Inflammasome and IFI16 Receptor

Recognition of DNA by the innate immune system is central to anti-viral and anti-bacterial defenses, as well as an important contributor to autoimmune diseases involving self DNA. AIM2 (absent in melanoma 2) and IFI16 (interferon-inducible protein 16) have been identified as DNA receptors that induc...

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Main Authors: Jin, Tengchuan, Perry, Andrew, Jiang, Jiansheng, Smith, Patrick, Curry, James A., Unterholzner, Leonie, Jiang, Zhaozhao, Horvath, Gabor, Rathinam, Vijay, Johnstone, Ricky W., Hornung, Veit, Latz, Eicke, Bowie, Andrew G., Fitzgerald, Katherine A., Xiao, T. Sam
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334467/
https://ncbi.nlm.nih.gov/pubmed/22483801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.02.014
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