Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells

The exchange of genetic information between donor and acceptor DNA molecules by homologous recombination (HR) depends on the cleavage of phosphodiester bonds. Although double-stranded and single-stranded DNA breaks (SSBs) have both been invoked as triggers of HR, until very recently the focus has be...

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Bibliographic Details
Main Authors: Gonçalves, Manuel A. F. V., van Nierop, Gijsbert P., Holkers, Maarten, de Vries, Antoine A. F.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3333848/
https://ncbi.nlm.nih.gov/pubmed/22189101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1234
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