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Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells
The exchange of genetic information between donor and acceptor DNA molecules by homologous recombination (HR) depends on the cleavage of phosphodiester bonds. Although double-stranded and single-stranded DNA breaks (SSBs) have both been invoked as triggers of HR, until very recently the focus has be...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3333848/ https://ncbi.nlm.nih.gov/pubmed/22189101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1234 |
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