Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease

Homologous recombination (HR) is a highly accurate mechanism of DNA repair that can be exploited for homology-directed gene targeting. Since in most cell types HR occurs very infrequently (∼10(−6) to 10(−8)), its practical application has been largely restricted to specific experimental systems that...

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Bibliographische Detailangaben
Hauptverfasser: van Nierop, Gijsbert P., de Vries, Antoine A. F., Holkers, Maarten, Vrijsen, Krijn R., Gonçalves, Manuel A. F. V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2009
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761290/
https://ncbi.nlm.nih.gov/pubmed/19651880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp643
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