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Identification of the product of Toxoflavin lyase: degradation via a Baeyer-Villiger oxidation

Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR and MS and was identified as a triazine in which the pyrimidine ring was oxidatively degraded. A mecha...

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Autors principals: Philmus, Benjamin, Abdelwahed, Sameh, Williams, Howard J., Fenwick, Michael K., Ealick, Steven E., Begley, Tadhg P.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3332044/
https://ncbi.nlm.nih.gov/pubmed/22304755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja211759n
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