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pVHL Mediates K63-Linked Ubiquitination of nCLU
pVHL, product of von Hippel-Lindau (VHL) tumor suppressor gene, functions as the substrate recognition component of an E3-ubiquitin ligase that targets proteins for ubiquitination and proteasomal degradation. Hypoxia-inducible factor α (HIFα) is the well-known substrate of pVHL. Besides HIFα, pVHL a...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3332038/ https://ncbi.nlm.nih.gov/pubmed/22532874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035848 |
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