TET is targeted for proteasomal degradation by the PHD-pVHL pathway to reduce DNA hydroxymethylation

Hypoxia-inducible factors are heterodimeric transcription factors that play a crucial role in a cell's ability to adapt to low oxygen. The von Hippel-Lindau tumor suppressor (pVHL) acts as a master regulator of HIF activity, and its targeting of prolyl hydroxylated HIF-α for proteasomal degrada...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Fan, Sijia, Wang, Jing, Yu, Guangqing, Rong, Fangjing, Zhang, Dawei, Xu, Chenxi, Du, Juan, Li, Zhi, Ouyang, Gang, Xiao, Wuhan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2020
Onderwerpen:
Gene Regulation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705310/
https://ncbi.nlm.nih.gov/pubmed/32963106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014538
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