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FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity
FBXO32 (MAFbx/Atrogin-1) is an E3 ubiquitin ligase that is markedly up-regulated in muscle atrophy. Although some data indicate that FBXO32 may play an important role in tumorigenesis, the molecular mechanism of FBXO32 in tumorigenesis has been poorly understood. Here, we present evidence that FBXO3...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4481220/ https://ncbi.nlm.nih.gov/pubmed/25944903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645978 |
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