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A unique regulatory phase of DNA methylation in the early mammalian embryo

DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methyl cytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and to...

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Dettagli Bibliografici
Autori principali: Smith, Zachary D., Chan, Michelle M., Mikkelsen, Tarjei S., Gu, Hongcang, Gnirke, Andreas, Regev, Aviv, Meissner, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331945/
https://ncbi.nlm.nih.gov/pubmed/22456710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10960
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