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Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis()

CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are required to restrain the immune system from mounting an autoaggressive systemic inflammatory response, but why their activity can prevent (or allow) organ-specific autoimmunity remains poorly understood. We have examined how TCR specificity contri...

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Библиографические подробности
Главные авторы: Oh, Soyoung, Aitken, Malinda, Simons, Donald M., Basehoar, Alissa, Garcia, Victoria, Kropf, Elizabeth, Caton, Andrew J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331886/
https://ncbi.nlm.nih.gov/pubmed/22450809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103598
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