Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck

BACKGROUND: Cell cycle deregulation is common in human cancer, and alterations of p27 and p21, two critical cell cycle regulators, have been implicated in the development of many human malignancies. Therefore, we hypothesize that p27 T109G polymorphism individually or in combination with p21 (C98A a...

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Hlavní autoři: Wang, Zhongqiu, Sturgis, Erich M, Zhang, Fenghua, Lei, Dapeng, Liu, Zhensheng, Xu, Li, Song, Xicheng, Wei, Qingyi, Li, Guojun
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331801/
https://ncbi.nlm.nih.gov/pubmed/22449259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-17
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