Loss of AMP-Activated Protein Kinase-α2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle

Whether the well-known metabolic switch AMP-activated protein kinase (AMPK) is involved in the insulin-sensitizing effect of calorie restriction (CR) is unclear. In this study, we investigated the role of AMPK in the insulin-sensitizing effect of CR in skeletal muscle. Wild-type (WT) and AMPK-α2(−/−...

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Detalhes bibliográficos
Main Authors: Wang, Pei, Zhang, Ruo-Yu, Song, Jie, Guan, Yun-Feng, Xu, Tian-Ying, Du, Hui, Viollet, Benoit, Miao, Chao-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331748/
https://ncbi.nlm.nih.gov/pubmed/22396207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1180
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