Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction’s effect on glucose uptake in skeletal muscle

Calorie restriction (CR; ~60% of ad libitum, AL, consumption) improves insulin-stimulated glucose uptake in skeletal muscle. The precise cellular mechanism for this healthful outcome is unknown, but it is accompanied by enhanced insulin-stimulated activation of Akt. Previous research using Akt2-null...

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Hlavní autoři: Sharma, Naveen, Arias, Edward B., Sequea, Donel A., Cartee, Gregory D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444632/
https://ncbi.nlm.nih.gov/pubmed/22846604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2012.07.012
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