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Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle
Calorie restriction (CR; ~60–65% of ad libitum, AL, consumption) can enhance insulin-stimulated glucose uptake (ISGU) in predominantly slow-twitch skeletal muscles (e.g., soleus) by an incompletely understood mechanism. We used an Akt inhibitor (MK-2206) to eliminate CR’s effect on insulin-stimulate...
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| Publicado no: | Appl Physiol Nutr Metab |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5228618/ https://ncbi.nlm.nih.gov/pubmed/27786542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1139/apnm-2016-0326 |
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