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Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle

Calorie restriction (CR; ~60–65% of ad libitum, AL, consumption) can enhance insulin-stimulated glucose uptake (ISGU) in predominantly slow-twitch skeletal muscles (e.g., soleus) by an incompletely understood mechanism. We used an Akt inhibitor (MK-2206) to eliminate CR’s effect on insulin-stimulate...

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書誌詳細
出版年:Appl Physiol Nutr Metab
主要な著者: Sharma, Naveen, Arias, Edward B., Cartee, Gregory D.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5228618/
https://ncbi.nlm.nih.gov/pubmed/27786542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1139/apnm-2016-0326
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