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Structural intermediates during α-synuclein fibrillogenesis on phospholipid vesicles
α-Synuclein (AS) fibrils are the main protein component of Lewy Bodies, the pathological hallmark of Parkinson’s disease and other related disorders. AS forms helices that bind phospholipid membranes with high affinity, but no atomic level data for AS aggregation in the presence of lipids is yet ava...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3331674/ https://ncbi.nlm.nih.gov/pubmed/22352310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja209019s |
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