E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity

Although an increased expression level of XIAP is associated with cancer cell metastasis, the underlying molecular mechanisms remain largely unexplored. To verify the specific structural basis of XIAP for regulation of cancer cell migration, we introduced different XIAP domains into XIAP(−/−) HCT116...

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Huvudupphovsmän: Liu, Jinyi, Zhang, Dongyun, Luo, Wenjing, Yu, Jianxiu, Li, Jingxia, Yu, Yonghui, Zhang, Xinhai, Chen, Jingyuan, Wu, Xue-Ru, Huang, Chuanshu
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330820/
https://ncbi.nlm.nih.gov/pubmed/22532870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035682
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