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RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and Its Inhibiting Cancer Cell Motility

The Rho GDP dissociation inhibitor (RhoGDI) can bind to small GTPases and keep them in a biologically inactive state in cytoplasm, through which it affects actin polymerization and cell motility. However, mechanisms underlying how RhoGDI regulates Rho GTPase complex formation/membrane extraction/GTP...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yu, Jianxiu, Zhang, Dongyun, Liu, Jinyi, Li, Jingxia, Yu, Yonghui, Wu, Xue-Ru, Huang, Chuanshu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340185/
https://ncbi.nlm.nih.gov/pubmed/22393046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337469
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