E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity

Although an increased expression level of XIAP is associated with cancer cell metastasis, the underlying molecular mechanisms remain largely unexplored. To verify the specific structural basis of XIAP for regulation of cancer cell migration, we introduced different XIAP domains into XIAP(−/−) HCT116...

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Библиографические подробности
Главные авторы: Liu, Jinyi, Zhang, Dongyun, Luo, Wenjing, Yu, Jianxiu, Li, Jingxia, Yu, Yonghui, Zhang, Xinhai, Chen, Jingyuan, Wu, Xue-Ru, Huang, Chuanshu
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330820/
https://ncbi.nlm.nih.gov/pubmed/22532870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035682
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