E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity

Although an increased expression level of XIAP is associated with cancer cell metastasis, the underlying molecular mechanisms remain largely unexplored. To verify the specific structural basis of XIAP for regulation of cancer cell migration, we introduced different XIAP domains into XIAP(−/−) HCT116...

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Main Authors: Liu, Jinyi, Zhang, Dongyun, Luo, Wenjing, Yu, Jianxiu, Li, Jingxia, Yu, Yonghui, Zhang, Xinhai, Chen, Jingyuan, Wu, Xue-Ru, Huang, Chuanshu
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330820/
https://ncbi.nlm.nih.gov/pubmed/22532870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035682
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