Cargando...

Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na(+) channel function of dorsal root ganglia

Opiates are potent analgesics for moderate to severe pain. Paradoxically, patients under chronic opiates have reported hypernociception, the mechanisms of which are unknown. Using standard patch-clamp technique, we examined the excitability, biophysical properties of tetrodotoxin-resistant (TTX-R) N...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Ross, Gracious R., Gade, Aravind R., Dewey, William L., Akbarali, Hamid I.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330728/
https://ncbi.nlm.nih.gov/pubmed/22189556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00171.2011
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!