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Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na(+) channel function of dorsal root ganglia

Opiates are potent analgesics for moderate to severe pain. Paradoxically, patients under chronic opiates have reported hypernociception, the mechanisms of which are unknown. Using standard patch-clamp technique, we examined the excitability, biophysical properties of tetrodotoxin-resistant (TTX-R) N...

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מידע ביבליוגרפי
Main Authors: Ross, Gracious R., Gade, Aravind R., Dewey, William L., Akbarali, Hamid I.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Physiological Society 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3330728/
https://ncbi.nlm.nih.gov/pubmed/22189556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00171.2011
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