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Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na(+) channel function of dorsal root ganglia
Opiates are potent analgesics for moderate to severe pain. Paradoxically, patients under chronic opiates have reported hypernociception, the mechanisms of which are unknown. Using standard patch-clamp technique, we examined the excitability, biophysical properties of tetrodotoxin-resistant (TTX-R) N...
में बचाया:
| मुख्य लेखकों: | , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Physiological Society
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3330728/ https://ncbi.nlm.nih.gov/pubmed/22189556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00171.2011 |
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