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Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na(+) channel function of dorsal root ganglia
Opiates are potent analgesics for moderate to severe pain. Paradoxically, patients under chronic opiates have reported hypernociception, the mechanisms of which are unknown. Using standard patch-clamp technique, we examined the excitability, biophysical properties of tetrodotoxin-resistant (TTX-R) N...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3330728/ https://ncbi.nlm.nih.gov/pubmed/22189556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00171.2011 |
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