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Role of β-arrestin-2 in short- and long-term opioid tolerance in the dorsal root ganglia

G-protein-biased agonists with reduced β-arrestin-2 activation are being investigated as safer alternatives to clinically-used opioids. β-arrestin-2 has been implicated in the mechanism of opioid-induced antinociceptive tolerance. Opioid-induced analgesic tolerance is classically considered as centr...

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Bibliografske podrobnosti
izdano v:Eur J Pharmacol
Main Authors: Muchhala, Karan H., Jacob, Joanna C., Dewey, William L., Akbarali, Hamid I.
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058323/
https://ncbi.nlm.nih.gov/pubmed/33705801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2021.174007
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