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Role of β-arrestin-2 in short- and long-term opioid tolerance in the dorsal root ganglia
G-protein-biased agonists with reduced β-arrestin-2 activation are being investigated as safer alternatives to clinically-used opioids. β-arrestin-2 has been implicated in the mechanism of opioid-induced antinociceptive tolerance. Opioid-induced analgesic tolerance is classically considered as centr...
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| Publicado no: | Eur J Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8058323/ https://ncbi.nlm.nih.gov/pubmed/33705801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2021.174007 |
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