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Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice

Drawbacks to opioid use include development of analgesic tolerance and persistent constipation. We previously reported that tolerance to morphine develops upon repeated exposure in the isolated ileum but not the isolated colon. The cellular mechanisms of antinociceptive tolerance vary among μ-opioid...

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Détails bibliographiques
Auteurs principaux: Maguma, Hercules T., Dewey, William L., Akbarali, Hamid I.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358422/
https://ncbi.nlm.nih.gov/pubmed/22521552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2012.04.001
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