Lack of p53 Decreases Basal Oxidative Stress Levels in the Brain Through Upregulation of Thioredoxin-1, Biliverdin Reductase-A, Manganese Superoxide Dismutase, and Nuclear Factor Kappa-B

Aims: The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((−/−))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of s...

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Main Authors: Barone, Eugenio, Cenini, Giovanna, Sultana, Rukhsana, Di Domenico, Fabio, Fiorini, Ada, Perluigi, Marzia, Noel, Teresa, Wang, Chi, Mancuso, Cesare, St. Clair, Daret K., Butterfield, D. Allan
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2012
Teme:
Forum Original Research CommunicationsMitochondria and Aging in Alzheimer's Disease (H. Reddy, Ed.)
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329952/
https://ncbi.nlm.nih.gov/pubmed/22229939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4124
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