Lack of p53 Decreases Basal Oxidative Stress Levels in the Brain Through Upregulation of Thioredoxin-1, Biliverdin Reductase-A, Manganese Superoxide Dismutase, and Nuclear Factor Kappa-B

Aims: The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((−/−))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of s...

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Main Authors: Barone, Eugenio, Cenini, Giovanna, Sultana, Rukhsana, Di Domenico, Fabio, Fiorini, Ada, Perluigi, Marzia, Noel, Teresa, Wang, Chi, Mancuso, Cesare, St. Clair, Daret K., Butterfield, D. Allan
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2012
Subjects:
Forum Original Research CommunicationsMitochondria and Aging in Alzheimer's Disease (H. Reddy, Ed.)
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329952/
https://ncbi.nlm.nih.gov/pubmed/22229939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4124
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