Lack of p53 Decreases Basal Oxidative Stress Levels in the Brain Through Upregulation of Thioredoxin-1, Biliverdin Reductase-A, Manganese Superoxide Dismutase, and Nuclear Factor Kappa-B

Aims: The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((−/−))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of s...

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Detalhes bibliográficos
Main Authors: Barone, Eugenio, Cenini, Giovanna, Sultana, Rukhsana, Di Domenico, Fabio, Fiorini, Ada, Perluigi, Marzia, Noel, Teresa, Wang, Chi, Mancuso, Cesare, St. Clair, Daret K., Butterfield, D. Allan
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Forum Original Research CommunicationsMitochondria and Aging in Alzheimer's Disease (H. Reddy, Ed.)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329952/
https://ncbi.nlm.nih.gov/pubmed/22229939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4124
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