Lack of p53 Decreases Basal Oxidative Stress Levels in the Brain Through Upregulation of Thioredoxin-1, Biliverdin Reductase-A, Manganese Superoxide Dismutase, and Nuclear Factor Kappa-B

Aims: The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((−/−))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of s...

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Autors principals: Barone, Eugenio, Cenini, Giovanna, Sultana, Rukhsana, Di Domenico, Fabio, Fiorini, Ada, Perluigi, Marzia, Noel, Teresa, Wang, Chi, Mancuso, Cesare, St. Clair, Daret K., Butterfield, D. Allan
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2012
Matèries:
Forum Original Research CommunicationsMitochondria and Aging in Alzheimer's Disease (H. Reddy, Ed.)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329952/
https://ncbi.nlm.nih.gov/pubmed/22229939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4124
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