Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

Aims: Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Aβ production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species (ROS) a...

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Bibliografski detalji
Glavni autori: Leuner, Kristina, Schütt, Tanja, Kurz, Christopher, Eckert, Schamim H., Schiller, Carola, Occhipinti, Angelo, Mai, Sören, Jendrach, Marina, Eckert, Gunter P., Kruse, Shane E., Palmiter, Richard D., Brandt, Ulrich, Dröse, Stephan, Wittig, Ilka, Willem, Michael, Haass, Christian, Reichert, Andreas S., Müller, Walter E.
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2012
Teme:
Forum Original Research CommunicationsMitochondria and Aging in Alzheimer's Disease (H. Reddy, Ed.)
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329950/
https://ncbi.nlm.nih.gov/pubmed/22229260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4173
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