Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

Aims: Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Aβ production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species (ROS) a...

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Autori principali: Leuner, Kristina, Schütt, Tanja, Kurz, Christopher, Eckert, Schamim H., Schiller, Carola, Occhipinti, Angelo, Mai, Sören, Jendrach, Marina, Eckert, Gunter P., Kruse, Shane E., Palmiter, Richard D., Brandt, Ulrich, Dröse, Stephan, Wittig, Ilka, Willem, Michael, Haass, Christian, Reichert, Andreas S., Müller, Walter E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2012
Soggetti:
Forum Original Research CommunicationsMitochondria and Aging in Alzheimer's Disease (H. Reddy, Ed.)
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329950/
https://ncbi.nlm.nih.gov/pubmed/22229260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4173
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