Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

Aims: Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Aβ production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species (ROS) a...

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Détails bibliographiques
Auteurs principaux: Leuner, Kristina, Schütt, Tanja, Kurz, Christopher, Eckert, Schamim H., Schiller, Carola, Occhipinti, Angelo, Mai, Sören, Jendrach, Marina, Eckert, Gunter P., Kruse, Shane E., Palmiter, Richard D., Brandt, Ulrich, Dröse, Stephan, Wittig, Ilka, Willem, Michael, Haass, Christian, Reichert, Andreas S., Müller, Walter E.
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2012
Sujets:
Forum Original Research CommunicationsMitochondria and Aging in Alzheimer's Disease (H. Reddy, Ed.)
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329950/
https://ncbi.nlm.nih.gov/pubmed/22229260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4173
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