Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

Aims: Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Aβ production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species (ROS) a...

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Detalhes bibliográficos
Main Authors: Leuner, Kristina, Schütt, Tanja, Kurz, Christopher, Eckert, Schamim H., Schiller, Carola, Occhipinti, Angelo, Mai, Sören, Jendrach, Marina, Eckert, Gunter P., Kruse, Shane E., Palmiter, Richard D., Brandt, Ulrich, Dröse, Stephan, Wittig, Ilka, Willem, Michael, Haass, Christian, Reichert, Andreas S., Müller, Walter E.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Forum Original Research CommunicationsMitochondria and Aging in Alzheimer's Disease (H. Reddy, Ed.)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329950/
https://ncbi.nlm.nih.gov/pubmed/22229260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4173
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