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“Splicing up” drug discovery. Cell-Based Expression and Screening of Genetically-Encoded Libraries of Backbone Cyclized Polypeptides

The present paper reviews the use of protein splicing for the biosynthesis of backbone cyclic polypeptides. This general method allows the in vivo and in vitro biosynthesis of cyclic polypeptides using recombinant DNA expression techniques. Biosynthetic access to backbone cyclic peptides opens the p...

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Detalhes bibliográficos
Main Authors: Sancheti, Harshkumar, Camarero, Julio A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329944/
https://ncbi.nlm.nih.gov/pubmed/19628015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2009.07.003
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