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“Splicing up” drug discovery. Cell-Based Expression and Screening of Genetically-Encoded Libraries of Backbone Cyclized Polypeptides

The present paper reviews the use of protein splicing for the biosynthesis of backbone cyclic polypeptides. This general method allows the in vivo and in vitro biosynthesis of cyclic polypeptides using recombinant DNA expression techniques. Biosynthetic access to backbone cyclic peptides opens the p...

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Autors principals: Sancheti, Harshkumar, Camarero, Julio A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329944/
https://ncbi.nlm.nih.gov/pubmed/19628015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2009.07.003
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