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2-Amidino Analogs of Glycine-Amiloride Conjugates: Inhibitors of Urokinase-type Plasminogen Activator

The relative non-toxicity of the diuretic amiloride, coupled with its selective inhibition of the protease urokinase plasminogen activator (uPA), makes this compound class attractive for structure-activity studies. Herein we substituted the C(2)-acylguanidine of C(5)-glycyl-amiloride with amidine an...

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Dettagli Bibliografici
Autori principali: Massey, Archna P., Harley, William R., Pasupuleti, NagaRekha, Gorin, Fredric A., Nantz, Michael H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329872/
https://ncbi.nlm.nih.gov/pubmed/22366654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.12.123
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