Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Aberrant Hedgehog (Hh) signaling is characteristic of the embryonal subtype (ERMS) and of fusion-negative alveolar RMS. In the mouse, ERMS-like tumors can be induced by mutations in the Hh receptor Patched1 (Ptch). As in huma...

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書誌詳細
主要な著者: Uhmann, Anja, Niemann, Hannah, Lammering, Bérénice, Henkel, Cornelia, Heß, Ina, Rosenberger, Albert, Dullin, Christian, Schraepler, Anke, Schulz-Schaeffer, Walter, Hahn, Heidi
フォーマット: Artigo
言語:Inglês
出版事項: Hindawi Publishing Corporation 2012
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329653/
https://ncbi.nlm.nih.gov/pubmed/22550417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/357040
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