PHOSPHORYLATION OF SERINE 21 MODULATES THE PROLIFERATION INHIBITORY MORE THAN THE DIFFERENTIATION INDUCING EFFECTS OF C/EBPα IN K562 CELLS

The CCAAT/Enhancer binding protein α (C/EBPα) is a transcription factor required for differentiation of myeloid progenitors. In acute myeloid leukemia (AML) cells expressing the constitutively active FLT3-ITD receptor tyrosine kinase, MAP kinase-dependent phosphorylation of serine 21 (S21) inhibits...

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Main Authors: Fragliasso, Valentina, Chiodo, Yuri, Ferrari-Amorotti, Giovanna, Soliera, Angela Rachele, Manzotti, Gloria, Cattelani, Sara, Candini, Olivia, Grisendi, Giulia, Vergalli, Jenny, Mariani, Samanta Antonella, Guerzoni, Clara, Calabretta, Bruno
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329570/
https://ncbi.nlm.nih.gov/pubmed/22212957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24040
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