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PHOSPHORYLATION OF SERINE 21 MODULATES THE PROLIFERATION INHIBITORY MORE THAN THE DIFFERENTIATION INDUCING EFFECTS OF C/EBPα IN K562 CELLS
The CCAAT/Enhancer binding protein α (C/EBPα) is a transcription factor required for differentiation of myeloid progenitors. In acute myeloid leukemia (AML) cells expressing the constitutively active FLT3-ITD receptor tyrosine kinase, MAP kinase-dependent phosphorylation of serine 21 (S21) inhibits...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3329570/ https://ncbi.nlm.nih.gov/pubmed/22212957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24040 |
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