Inhibiting interactions of lysine demethylase LSD1 with Snail/Slug blocks cancer cell invasion

The process of epithelial-mesenchymal transition (EMT) which is required for cancer cell invasion is regulated by a family of E-box binding transcription repressors which include Snail (SNAI) and Slug (SNAI2). Snail appears to repress the expression of the EMT marker E-cadherin by epigenetic mechani...

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Detalhes bibliográficos
Main Authors: Ferrari-Amorotti, Giovanna, Fragliasso, Valentina, Esteki, Rosa, Prudente, Zelia, Soliera, Angela Rachele, Cattelani, Sara, Manzotti, Gloria, Grisendi, Giulia, Dominici, Massimo, Pieraccioli, Marco, Raschellà, Giuseppe, Chiodoni, Claudia, Colombo, Mario Paolo, Calabretta, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537890/
https://ncbi.nlm.nih.gov/pubmed/23054398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1739
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