Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPα

Chronic phase–to–blast crisis transition in chronic myelogenous leukemia (CML) is associated with differentiation arrest and down-regulation of C/EBPα, a transcription factor essential for granulocyte differentiation. Patients with CML in blast crisis (CML-BC) became rapidly resistant to therapy wit...

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Detalhes bibliográficos
Main Authors: Ferrari-Amorotti, Giovanna, Keeshan, Karen, Zattoni, Michela, Guerzoni, Clara, Iotti, Giorgio, Cattelani, Sara, Donato, Nick J., Calabretta, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895881/
https://ncbi.nlm.nih.gov/pubmed/16670262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-011833
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