Transcriptional repression of c-Myb and GATA-2 is involved in the biologic effects of C/EBPα in p210(BCR/ABL)-expressing cells

Ectopic C/EBPα expression in p210(BCR/ABL)-expressing hematopoietic cells induces granulocytic differentiation, inhibits proliferation, and suppresses leukemogenesis. To assess the underlying mechanisms, C/EBPα targets were identified by microarray analyses. Upon C/EBPα activation, expression of c-M...

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Autors principals: Soliera, Angela Rachele, Lidonnici, Maria Rosa, Ferrari-Amorotti, Giovanna, Prisco, Marco, Zhang, Ying, Martinez, Robert V., Donato, Nick J., Calabretta, Bruno
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518896/
https://ncbi.nlm.nih.gov/pubmed/18550858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-114975
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