Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage

UV-induced cyclobutane pyrimidine dimers (CPDs) in the template DNA strand stall transcription elongation by RNA polymerase II (Pol II). If the nucleotide excision repair machinery does not promptly remove the CPDs, stalled Pol II creates a roadblock for DNA replication and subsequent rounds of tran...

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Hauptverfasser: Walmacq, Celine, Cheung, Alan C.M., Kireeva, Maria L., Lubkowska, Lucyna, Ye, Chengcheng, Gotte, Deanna, Strathern, Jeffrey N., Carell, Thomas, Cramer, Patrick, Kashlev, Mikhail
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329276/
https://ncbi.nlm.nih.gov/pubmed/22405652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.02.006
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