Genetic analysis of Down syndrome facilitated by mouse chromosome engineering

Human trisomy 21 is the most frequent live-born human aneuploidy and causes a constellation of disease phenotypes classified as Down syndrome, which include heart defects, myeloproliferative disorder, cognitive disabilities and Alzheimer-type neurodegeneration. Because these phenotypes are associate...

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Main Authors: Zhang, Li, Fu, Dawei, Belichenko, Pavel V., Liu, Chunhong, Kleschevnikov, Alexander M., Pao, Annie, Liang, Ping, Clapcote, Steven J., Mobley, William C., Yu, Y. Eugene
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Commentary
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329253/
https://ncbi.nlm.nih.gov/pubmed/22126738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bbug.3.1.17696
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