Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes

Doxorubicin, a commonly prescribed chemotherapeutic agent, causes skeletal muscle wasting in cancer patients undergoing treatment and increases mitochondrial reactive oxygen species (ROS) production. ROS stimulate protein degradation in muscle by activating proteolytic systems that include caspase-3...

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Détails bibliographiques
Auteurs principaux: Gilliam, Laura A. A., Moylan, Jennifer S., Patterson, Elaine W., Smith, Jeffrey D., Wilson, Anne S., Rabbani, Zaheen, Reid, Michael B.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2012
Sujets:
Muscle Cell Biology and Cell Motility
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328915/
https://ncbi.nlm.nih.gov/pubmed/21940668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00217.2011
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