A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes

The accumulation of sphingolipids in obesity leads to impairments in insulin sensitivity and mitochondrial metabolism, but the precise species driving these defects is unclear. We have modeled these obesity-induced effects in cultured C2C12 myotubes, using BSA-conjugated palmitate to increase synthe...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Park, Min, Kaddai, Vincent, Ching, Jianhong, Fridianto, Kevin T., Sieli, Ryan J., Sugii, Shigeki, Summers, Scott A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104923/
https://ncbi.nlm.nih.gov/pubmed/27703011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737684
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