Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes

Doxorubicin, a commonly prescribed chemotherapeutic agent, causes skeletal muscle wasting in cancer patients undergoing treatment and increases mitochondrial reactive oxygen species (ROS) production. ROS stimulate protein degradation in muscle by activating proteolytic systems that include caspase-3...

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Detaylı Bibliyografya
Asıl Yazarlar: Gilliam, Laura A. A., Moylan, Jennifer S., Patterson, Elaine W., Smith, Jeffrey D., Wilson, Anne S., Rabbani, Zaheen, Reid, Michael B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2012
Konular:
Muscle Cell Biology and Cell Motility
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328915/
https://ncbi.nlm.nih.gov/pubmed/21940668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00217.2011
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