Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes

Doxorubicin, a commonly prescribed chemotherapeutic agent, causes skeletal muscle wasting in cancer patients undergoing treatment and increases mitochondrial reactive oxygen species (ROS) production. ROS stimulate protein degradation in muscle by activating proteolytic systems that include caspase-3...

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Detalhes bibliográficos
Main Authors: Gilliam, Laura A. A., Moylan, Jennifer S., Patterson, Elaine W., Smith, Jeffrey D., Wilson, Anne S., Rabbani, Zaheen, Reid, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Muscle Cell Biology and Cell Motility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328915/
https://ncbi.nlm.nih.gov/pubmed/21940668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00217.2011
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