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Bone Morphogenetic Protein-2-Induced Signaling and Osteogenesis Is Regulated by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension

Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is classically thought to be mediated by different cytokines such as the bone morphogenetic proteins (BMPs). Here, we report that cell adhesion to extracellular matrix (ECM), and its effects on cell shape and cytoskeletal mechanics,...

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Detalhes bibliográficos
Main Authors: Wang, Yang-Kao, Yu, Xiang, Cohen, Daniel M., Wozniak, Michele A., Yang, Michael T., Gao, Lin, Eyckmans, Jeroen, Chen, Christopher S.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328763/
https://ncbi.nlm.nih.gov/pubmed/21967638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2011.0293
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