Development of novel inhibitor probes of DNA polymerase III based on dGTP analogs of the HPUra type: base, nucleoside and nucleotide derivatives of N2-(3,4-dichlorobenzyl)guanine.

6-(p-Hydroxyphenylhydrazino)uracil (H2-HPUra) is a selective and potent inhibitor of the replication-specific class III DNA polymerase (pol III) of Gr+ bacteria. Although formally a pyrimidine, H2-HPUra derives its inhibitory activity from its specific capacity to mimic the purine nucleotide, dGTP....

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Butler, M M, Dudycz, L W, Khan, N N, Wright, G E, Brown, N C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 1990
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC332876/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2259629/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/18.24.7381
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